She said she felt it was unfair Scotland had to leave the European Union when the majority of the country voted to remain.
But she was met with little sympathy from panellist Carol McGiffin who was quick to remind Sturgeon the referendum was a “national” decision and voted for by the British public.
Sturgeon said: “Scotland, we voted against Brexit and yet we face being ripped out of the European Union.
“Independence, it’s not a rejection of people in England, it’s just about re-setting that relationship so it is one of equals, where we can’t be forced down paths we don’t want to go down.”
McGiffin hit back: “Why are you so against Great Britain being independent of the European Union then?
“Because you want to stop Brexit but you want to be independent from the UK.”
Sturgeon responded: “I think the two things are very different.
“Every single country in the EU is an independent country…look at Ireland, just now, a small country, but it’s got enormous clout in Europe.
“Contrast that with the position Scotland’s in, we’re kind of being told we have to leave the EU no matter what.”
ITV Loose Women: 'It was a national referendum' Sturgeon shut down as she slams Brexit
But McGiffin wasn’t impressed as she shut down Sturgeon, reminding her: “Because you’re part of the country.
“You do have your own Parliament but the decision's made. The decision was made by the public. It was a national referendum.
Sturgeon replied: “The Remainers won in Scotland. You’re kind of making my point."
McGiffin snapped back: “But they won in London too - but what does that mean?”
“London, I’m a great fan of, but it’s not a country in the way that Scotland is,” Sturgeon remarked.
“If the argument for Scotland remaining in the current system then you just have to accept being outvoted all the time.”
During her appearance on the show, Sturgeon also opened up about what she thought of Boris Johnson.
“Boris and I are not very alike,” she told the panel.
“It’s not just men, I don’t want it to sound like I’m having a go at men all the time. Boris just talks nonsense, but he has that swagger and confidence and conviction.
“Despite the swagger, it’s still nonsense. I’m sure he does [think I speak nonsense, too].”
Loose Women airs weekdays on ITV at 12.30pm.